The Etv2-miR-130a Network Regulates Mesodermal Specification

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The Etv2-miR-130a Network Regulates Mesodermal Specification.

MicroRNAs (miRNAs) are known to regulate critical developmental stages during embryogenesis. Here, we defined an Etv2-miR-130a cascade that regulates mesodermal specification and determination. Ablation of Dicer in the Etv2-expressing precursors resulted in altered mesodermal lineages and embryonic lethality. We identified miR-130a as a direct target of Etv2 and demonstrated its role in the seg...

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ژورنال

عنوان ژورنال: Cell Reports

سال: 2015

ISSN: 2211-1247

DOI: 10.1016/j.celrep.2015.09.060